Demi Moore gives a career-best and Golden Globe®-winning performance as Elisabeth Sparkle, a former A-lister past her prime and suddenly fired from her fitness TV show by repellent studio head Harvey (Dennis Quaid). She is then drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE. All it takes is one injection and she is reborn – temporarily – as the gorgeous, twentysomething Sue (Margaret Qualley).

The only rule? Time needs to be split: exactly one week in one body, then one week in the other. No exceptions.  A perfect balance. What could go wrong?

Deliriously entertaining and ruthlessly satirical, Coralie Fargeat’s explosive Cannes sensation turns toxic beauty culture inside out with a be-careful-what-you-wish-for fable for the ages. Explosive, provocative and twisted, THE SUBSTANCE marks the arrival of a thrillingly visionary filmmaker, now nominated for 5 Academy Awards® including Best Picture.

5 ACADEMY AWARD NOMINATIONS!
Best Motion Picture
Best Actress – Demi Moore
Best Director – Coralie Fargeat
Best Original Screenplay – Coralie Fargeat
Best Hair and Makeup Styling